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| CAS Number | 195875-84-4 |
|---|---|
| Molecular Formula | C18H31N5O9 |
| Molecular Weight | 461.46 g/mol |
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Livagen 20mg is a synthetic tetrapeptide bioregulator with the amino acid sequence Lys-Glu-Asp-Ala (KEDA), developed by Professor Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology. Derived from liver tissue extracts, it is classified as a hepatic bioregulator — a short-chain peptide studied for its tissue-specific regulatory activity in hepatocytes and hepatic stellate cells through chromatin remodeling and direct DNA interaction.
Research interest in Livagen centers on its proposed ability to promote chromatin decondensation in liver cells, potentially reactivating genes responsible for protein synthesis and hepatocyte renewal that are progressively silenced during cellular aging. Preclinical studies have examined its effects across multiple hepatic research models: in experimental acute hepatitis models, Livagen demonstrated normalization of bilirubin, cholesterol, ALT, and AST markers; in liver fibrosis models, both hepatoprotective and immunoprotective effects were observed — with maximum efficacy noted in aged animals, consistent with the bioregulator hypothesis that KEDA primarily restores age-depleted signaling.
Beyond hepatic research, Livagen has also been studied for its effects on lymphocyte populations, showing modulation of CD3+, CD4+, and CD8+ markers, generating interest in combined hepatic-immune aging research protocols.
Beyond Health Lab supplies Livagen 20mg as a research-grade lyophilized compound, HPLC-verified for 99% purity, shipped within 24 hours from our Mexico facility.
For research use only. Not intended for human or animal consumption.
FAQ:
What is Livagen and what tissue does it target?
Livagen is a Khavinson tetrapeptide bioregulator (Lys-Glu-Asp-Ala / KEDA) derived from liver tissue extracts and studied for its tissue-specific regulatory activity in hepatocytes and hepatic stellate cells. Its proposed mechanism involves chromatin decondensation — loosening tightly packed DNA to reactivate genes involved in protein synthesis and hepatocyte function that become silenced during aging. Its molecular weight is 461.47 g/mol (C₁₈H₃₁N₅O₉).
What hepatic research models has Livagen been studied in?
Published preclinical research from the Khavinson group and a 2020 review by Kuznik, Khavinson, and Linkova have examined Livagen in experimental acute hepatitis, chronic hepatitis, and liver fibrosis animal models. Studies documented normalization of bilirubin and cholesterol levels, restoration of ALT and AST enzyme markers, stimulation of tissue repair in liver stroma, and normalization of glycogen-containing hepatocytes — markers of hepatocyte metabolic function.
How does Livagen compare to Epithalon or Cardiogen in the Khavinson system?
Within the Khavinson bioregulator family, each peptide is organ-specific. Livagen targets hepatic tissue, Cardiogen targets cardiac muscle, Epithalon targets the pineal gland, and Prostamax targets the prostate. Livagen is notable for its dual hepatic and immune research profile — uniquely among the Khavinson compounds, it has been studied for lymphocyte population modulation alongside its liver-specific effects, making it relevant to combined hepatic-immune aging research designs.
How should Livagen 20mg be stored?
Store lyophilized Livagen at 2–8°C away from light and moisture. Once reconstituted with bacteriostatic water, keep refrigerated and use within 28 days for optimal stability and research-grade performance.
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Peptides are short amino acid chains that function as vital signaling molecules throughout the body. They play a primary role in a vast array of biological functions, including tissue regeneration, immune modulation, and intercellular communication.
In clinical research, peptides are utilized to investigate interactions with specific receptors and metabolic pathways, serving as essential tools for advanced scientific and laboratory analysis.
All products provided by Beyond Health Lab are intended strictly for research and laboratory purposes. These compounds are not approved for human consumption.
To ensure long-term stability during shipping and storage, all peptides from Beyond Health Lab are supplied in a lyophilized (freeze-dried) state.
Unreconstituted Vials: Store in a cool, dry environment away from direct light. For extended shelf life, refrigeration is highly recommended.
Reconstituted Peptides: Once prepared for research, solutions must be kept refrigerated and handled using sterile laboratory practices to maintain molecular integrity.
Stability & Purity: Proper storage and handling are critical to preserving peptide purity, stability, and experimental accuracy.
All orders are processed and shipped directly from our fulfillment center within 24 hours (Monday–Friday) to ensure fast and reliable delivery.
Transit Time: Delivery typically occurs within 2–5 business days, depending on your location and the selected shipping method.
Carrier Partners: We collaborate with trusted carriers to ensure secure and, where necessary, temperature-stable transit.
Tracking: Upon shipment, a confirmation email with a real-time tracking number is provided to monitor the package at every stage.
To ensure accuracy and consistency for research applications, each vial contains approximately 105% of the labeled peptide amount.
Formulation: All products are supplied as a lyophilized (freeze-dried) powder.
Reconstitution: Vials require reconstitution with bacteriostatic water prior to use. We do not ship peptides in a liquid state to ensure maximum stability.
Standardized Dimensions: Vials are standardized at 16mm in diameter and 38mm in height, with a maximum fill capacity of 3ml. This ensures compatibility with common laboratory storage and reconstitution tools.
Transparency and accuracy are central to our operations. All peptides offered by Beyond Health Lab undergo rigorous quality-control procedures to ensure they meet high industry standards.
Third-Party Testing: Every batch is subject to independent, third-party analytical testing for purity, identity, and consistency.
Advanced Methodology: We utilize High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry to verify that each peptide meets required research-grade standards.
Certificates of Analysis (COAs): Full COAs, including purity percentages and molecular confirmation, are available upon request for every batch before it is released.
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